Dr. Sam Chambers is a interdisciplinary scientist with expertise in counter-forensics, spatiotemporal analysis, and biometeorology. Currently, his research focuses on investigating the human body's reactions to extreme environments within the world's borderlands. Specifically, he delves into the evolving geographic patterns of mortality among undocumented border crossers, shedding light on how 'security' infrastructure and surveillance technology drive these outcomes. Dr. Chambers' work transcends mere identification of natural causes of death, and has revealed them as a direct consequence of border militarization.

His primary research area centers on the U.S.-Mexico border, yet his scholarly pursuits extend globally, including investigations of migration routes and military operations in North Africa's Sahara Desert. Dr. Chambers' contributions have garnered attention from various international media outlets, as well as humanitarian and search and rescue organizations, underscoring the significance of his research in addressing pressing societal concerns.

In addition to the forensic analysis of border systems, Dr. Chambers has also studied the effects of human infrastructure on wildlife behavior and physiology and the accessibility of care and transportation to people in urban heat extremes.